Fold Versus Relative Difference

Fold
Relative
Difference
10.00
1.250.22
1.50.40
1.750.55
20.67
2.250.77
2.50.86
2.750.93
31.00
3.251.06
3.51.11
3.751.16
41.20
4.251.24
4.51.27
4.751.30
51.33
5.251.36
5.51.38
5.751.41
61.43
6.251.45
6.51.47
6.751.48
71.50
7.251.52
7.51.53
7.751.54
81.56
8.251.57
8.51.58
8.751.59
91.60
9.251.61
9.51.62
9.751.63
101.64

Relative Difference = (T - C) / ((T + C) / 2)
It has proven to be better than a simple ratio or log2 (ratio) in spike-in dataset comparisions.
Ratio = (RD + 2) / (2 - RD)